HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Ethyl (3S)-2-[(methylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | ethyl (3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylate | HCID 1079579 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl (3S)-2-[(methylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate | HCID 13561983 | 68% |
Reaction Steps
In the same manner as described in Example 53, ethyl (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (2.50 g), triethylamine (1.34 g), carbon disulfide (0.82 ml), ethanol (60 ml) and methyl iodide (0.84 ml) are reacted and treated. The product is recrystallized from ethyl acetate-n-hexane to give the title compound (2.55 g, 68%) as colorless prisms, m.p. 138°-140° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04628057 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-b0209ac9f2e9498da3e391f85d850859 |
| Source note | uspto-grants-1986_12 |