HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Disulfide → Ethyl (3S)-2-[(2-thenylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(Chloromethyl)thiophene | HCID 69830 | — |
| Reactant | ethyl (3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylate | HCID 1079579 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl (3S)-2-[(2-thenylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate | HCID 13561986 | 62% |
Reaction Steps
In the same manner as described in Example 53, ethyl (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (2.24 g), triethylamine (1.20 g), carbon disulfide (0.73 ml), ethanol (50 ml) and 2-thenyl chloride (1.59 g) are reacted and treated. The product is recrystallized from ethyl acetate-n-hexane to give the title compound (2.57 g, 62%) as colorless needles, m.p. 206°-207° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04628057 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-cdcfc9955e29401cb1a8fec8e7bf655a |
| Source note | uspto-grants-1986_12 |