Diazomethane → Methyl (1S,3S)-1-methyl-2-[(methylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate

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Reaction Steps

A mixture of (1S,3S)-1-methyl-2-[(methylthio)thiocarbonyl]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (1.28 g), diazomethane [prepared from N-nitrosomethylurea (3.0 g) and 40% NaOH (9 ml)] and ether (100 ml) is allowed to stand under ice-cooling overnight. The resulting precipitates are collected by filtration and dried to give the title compound (1.09 g, 82%), m.p. 229°-230° C.

Provenance & Evidence