Methyl iodide → Methyl (3RS)-9-methyl-2-[(methylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate

Participants

Reaction Steps

In the same manner as described in Example 53, methyl (3RS)-9-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate hydrochloride (5.61 g), triethylamine (4.86 g), carbon disulfide (1.83 g), methanol (200 ml) and methyl iodide (3.40 g) are reacted and treated. The product is recrystallized from methanol to give the title compound (5.38 g, 80.5%) as colorless needles, m.p. 170°-171° C.

Provenance & Evidence