HCID 86741156, compound → HCID 754468, compound

Participants

Reaction Steps

Methyl (1RS,3SR)-trans-2-benzyl-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (14.0 g) is dissolved in methanol (600 ml), and thereto is added 10% Pd-C (1.0 g). The mixture is subjected to catalytic reduction under atmospheric pressure. After the reaction, the catalyst is removed by filtration and washed with methanol. The filtrate and the washing liquid are combined and distilled to remove the solvent. The residue is recrystallized from methanol-isopropyl ether to give the title compound (10.08 g, 98.5%) as colorless prisms, m.p. 152°-154° C.

Provenance & Evidence