Sodium Hydroxide → HCID 675100, compound

Participants

Reaction Steps

Methyl (1RS,3SR)-trans-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (2.44 g) is dissolved in methanol (30 ml), and thereto is added 1N NaOH (13 ml). The mixture is stirred at room temperature for 3 hours, and the solvent is distilled off under reduced pressure. The residue is dissolved in water and is acidified with 10% HCl. The precipitated crystals are collected by filtration, washed with water and dried to give the title compound (2.21 g, 90%) as colorless needles, m.p. 242°-244° C. (recrystallized from aqueous ethanol).

Provenance & Evidence