Sodium Hydroxide → HCID 905964, compound

HRID 1249089Notes

Reaction equation

HRID 1249089 reaction equation
[CH2:1]([C@H:3]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH2:6][C@@H:5]([C:16]([OH:18])=[O:17])[NH:4]1)[CH3:2].C([C@H]1C2NC3C(=CC=CC=3)C=2C[C@H](C(OC)=O)N1)C.[OH-].[Na+]>CO>[CH2:1]([C@H:3]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH2:6][C@H:5]([C:16]([OH:18])=[O:17])[NH:4]1)[CH3:2]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 178220(1S,3S)-1-Ethyl-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acidHCID 40538205HCID 40538205, compound

Product 1

HCID 905964HCID 905964, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the same manner as described above (1) using methyl (1RS,3SR)-trans-1-ethyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (2.58 g), 1N NaOH (15 ml) and methanol (30 ml), there is obtained the title compound (1.50 g, 61.4%) as colorless needles, m.p. 242°-243° C. (recrystallized from aqueous methanol).

Workup

  1. customthere is obtained
  2. customthe title compound (1.50 g, 61.4%) as colorless needles, m.p. 242°-243° C. (recrystallized from aqueous methanol)

Sources & evidence

ORD record
ord-400ca180f7cf428395d2a698384c0995
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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