Sodium Hydroxide → 98667-12-0

HRID 1249093Notes

Reaction equation

HRID 1249093 reaction equation
[OH:1][CH2:2][C@H:3]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH2:6][C@@H:5]([C:16]([O:18]C)=[O:17])[NH:4]1.[OH-].[Na+]>CO>[OH:1][CH2:2][C@H:3]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH2:6][C@@H:5]([C:16]([OH:18])=[O:17])[NH:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12789155HCID 12789155, compound

Product 1

HCID 699761698667-12-0Yield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the same manner as described in Reference Example 2-(1) using methyl (1RS,3RS)-cis-1-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (3.124 g), 1N NaOH (13.2 ml) and methanol (550 ml), there is obtained the title compound (2.66 g, 90%), m.p. 241°-242° C.

Sources & evidence

ORD record
ord-4afae077f3ad4119932b5943c2e17ec4
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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