反应详情

L-Tryptophan methyl ester hydrochloride (5.09 g) is dissolved in methanol (60 ml) and thereto is added 35% formalin (1.89 g). The mixture is stirred at room temperature overnight, and the solvent is distilled off. The residue is recrystallized from methanol to give the title compound (4.42 g, 82.9%) as colorless needles, m.p. 250°-253° C.

1. distillationthe solvent is distilled off
2. customThe residue is recrystallized from methanol