Sodium Hydroxide → HCID 762192, compound

HRID 1249106Notes

Reaction equation

HRID 1249106 reaction equation
[CH2:1]([C@H:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][C@@H:6]([C:17]([OH:19])=[O:18])[NH:5]1)[CH2:2][CH3:3].C([C@H]1C2NC3C(=CC=CC=3)C=2C[C@H](C(OC)=O)N1)CC.[OH-].[Na+]>CO>[CH2:1]([C@H:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][C@H:6]([C:17]([OH:19])=[O:18])[NH:5]1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 762190HCID 762190, compoundHCID 10683615HCID 10683615, compound

Product 1

HCID 762192HCID 762192, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the same manner as described above (2) using methyl (1RS,3SR)-trans-1-n-propyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (1.36 g), 1N NaOH (6 ml) and methanol (20 ml), there is obtained the title compound (1.01 g, 78%) as colorless needles, m.p. 210°-211° C.

Sources & evidence

ORD record
ord-262bac66daa148589baee5cfae510112
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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