反应详情

N-Methylmethanesulfonamide (21.8 grams; 0.2 mol), t-butylalcohol (50 ml) sodium hydride (0.5 grams; 50% in mineral oil), and propylene oxide (11.6 grams; 0.2 mol) were placed into a 3-necked glass reaction flask equipped with stopper, stirrer, thermometer, and reflux condenser. The mixture was heated at 50°-60° C. for three hours, cooled, and concentrated on a rotoevaporator. The concentrate was neutralized with concentrated hydrochloric acid (1 ml) and distilled under reduced pressure. Fractions 4 and 5 (13.2 grams; boiling point (140°-142° C./1.5 mm Hg) analyzed for the described product as follows:

1. customequipped with stopper, stirrer
2. temperaturethermometer, and reflux condenser
3. temperatureThe mixture was heated at 50°-60° C. for three hours
4. temperaturecooled
5. concentrationconcentrated on a rotoevaporator
6. distillationdistilled under reduced pressure
7. custompoint (140°-142° C./1.5 mm Hg)