Sodium → HCID 178427408, compound

Participants

Reaction Steps

N-Bromomethyl-4-(p-toluenesulfonamido)phthalimide (13 g) was dissolved in tetrahydrofuran (200 ml) and thereto a tetrahydrofuran solution (100 ml) of the sodium salt of 5-mercapto-1-phenyltetrazole (6 g) was slowly added at room temperature. The reaction mixture was allowed to stand at room temperature for 2 hours. Thereafter, the reaction mixture was poured into ice-cold water, and the crystals precipitated were recovered by filtration to obtain a crude product. The thus obtained crude product was recrystallized from an ethyl acetate/methanol mixed solvent to yield 15.4 g of N-(1-phenyl-5-tetrazolylthiomethyl)-4-(p-toluenesulfonamido)phthalimide. Melting Point: 202°-204° C.

Provenance & Evidence