3-Methyl-2-butanone → 2-Methyl-2-(trifluoromethylthio)butan-3-one

HRID 1249144Notes

Reaction equation

HRID 1249144 reaction equation
[CH:1]([C:4]([CH3:6])=[O:5])([CH3:3])[CH3:2].[F:7][C:8]([F:12])([F:11])[S:9]Cl>C(Cl)Cl>[CH3:2][C:1]([S:9][C:8]([F:12])([F:11])[F:7])([CH3:3])[C:4](=[O:5])[CH3:6]

Participants

4

Reactant 2

HCID 112513-Methyl-2-butanoneHCID 67900Methanesulfenyl chloride, trifluoro-

Product 1

HCID 131173002-Methyl-2-(trifluoromethylthio)butan-3-oneYield 80.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

334 g of methyl isopropyl ketone in 1.2 liters of methylene chloride were initially introduced into a narrow stirred vessel equipped with a condenser. 220 g of trifluoromethane-sulphenyl chloride were introduced, at room temperature in the course of 4 hours, through an inlet tube extending to the bottom of the vessel. The reaction mixture was allowed to stand overnight. It was then distilled. 242 g (80.7% of theory) of crude 3-methyl-3-trifluoromethylthio-butan-2-one were obtained and purified by fractional distillation: boiling point: 60° C./50 mbar and refractive index nD20 =1.4030. ##STR12##

Workup

  1. customequipped with a condenser
  2. distillationIt was then distilled

Sources & evidence

ORD record
ord-8e3b9fac0f7a425a9240cd8cff7bca01
Source dataset
uspto-grants-1986_12
Patent number
US04629732

Reaction notes

Loading…