Bromine → 1-Bromo-3-methyl-3-trifluoromethylthio-butan-2-one
Reaction equation
[CH3:1][C:2]([S:7][C:8]([F:11])([F:10])[F:9])([CH3:6])[C:3](=[O:5])[CH3:4].[Br:12]Br>C(Cl)(Cl)Cl>[Br:12][CH2:4][C:3](=[O:5])[C:2]([CH3:1])([S:7][C:8]([F:10])([F:11])[F:9])[CH3:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 40 °C
Procedure
3-Methyl-3-trifluoromethylthio-butan-2-one was dissolved in chloroform and bromine was added dropwise at 20° C. at such a rate that decolorization occurred continuously. Addition was stopped when the color persisted, the reaction mixture was further stirred at 40° C. 1-Bromo-3-methyl-3-trifluoromethylthio-butan-2-one of boiling point 56° C./0.4 mbar was obtained in a yield of 85%. ##STR13##
Workup
- additionAddition
Sources & evidence
- ORD record
- ord-081686470629422b9e3c3b323def5179
- Source dataset
- uspto-grants-1986_12
- Patent number
- US04629732
Reaction notes
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