Water → 1-Bromo-1-(4-chlorophenoxy)-3-methyl-3-trifluoromethylthio-butan-2-one

HRID 1249147Notes

Reaction equation

[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][CH2:7][C:8](=[O:17])[C:9]([CH3:16])([S:11][C:12]([F:15])([F:14])[F:13])[CH3:10])=[CH:4][CH:3]=1.[Br:20]Br.O>C(Cl)(Cl)Cl>[Br:20][CH:7]([O:6][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:19][CH:18]=1)[C:8](=[O:17])[C:9]([CH3:16])([S:11][C:12]([F:13])([F:14])[F:15])[CH3:10]

Participants

Conditions

Temperature: 40 °C

Procedure

45 g (0.15 mol) of 1-(4-chlorophenoxy)-3-methyl-3-trifluoromethylthio-butan-2-one were dissolved in 150 ml of chloroform, and 7.5 ml (0.15 mol) of bromine were added dropwise at 20° C. at such a rate that decolorization occurred continuously. After the end of the addition, the reaction mixture was further stirred at 40° C. for 20 minutes and was then introduced into water. The mixture was extracted with chloroform and concentrated at 40° C. 1-Bromo-1-(4-chlorophenoxy)-3-methyl-3-trifluoromethylthio-butan-2-one was obtained quantitatively and was directly further reacted. ##STR15##

Workup

additionAfter the end of the addition
extractionThe mixture was extracted with chloroform
concentrationconcentrated at 40° C

Sources & evidence

ORD record: ord-31bea41923904d478e566ac2fcddb825
Source dataset: uspto-grants-1986_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04629732

Reaction notes

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