反应详情

29 g (0.075 mol) of crude 1-bromo-1-(4-chlorophenoxy)-3-methyl-3-trifluoromethylthio-butan-2-one and 16 g (0.25 mol) of 1,2,4-triazole in 150 ml of acetonitrile were heated under reflux for 1 hour. Thereafter, the mixture was concentrated and the residue was taken up with methylene chloride/water. The organic phase was separated off, dried over sodium sulphate and concentrated again. The oil residue was chromatographed. 10.4 g (37% of theory) of 1-(4-chlorophenoxy)-3-methyl-1-(1,2,4-triazol-1-yl)-3-trifluoromethylthio-butan-2-one of melting point 66° C. were obtained.

1. temperatureunder reflux for 1 hour
2. concentrationThereafter, the mixture was concentrated
3. customThe organic phase was separated off
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated again
6. customThe oil residue was chromatographed