Formic Acid → HCID 86741159, compound

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Reaction Steps

Trans-4-amino-6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ol *(0.90 g) was heated under reflux in formic acid (15 ml) and pyridine (1 ml) during 19 hr. The cooled solutions was poured into water and extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous magnesium sulphate. Filtration and evaporation left an orange coloured oil which was chromatographed (chromatotron, ethyl acetate-pentane gradient elution on 2 mm silica gel, flow rate 9 ml/min) to give after recrystallisation from ethyl acetate-pentane the title compound (0.15 g) as crystals of m.p. 171°-172° C.

Provenance & Evidence