Chloroacetyl chloride → HCID 13279949, compound

Participants

Reaction Steps

A solution of chloroacetylchloride (3 g) in dry ether was added dropwise to a stirred solution of [1-(3,4-dichlorophenyl)cyclobutyl]methylamine (6.2 g prepared from the hydrochloride salt described above) and triethylamine (2.9 g) in dry ether (20 ml) at a temperature of 5° to 10° C. The mixture was stirred for four hours, filtered and the filtrate washed with water, dried and evaporated to give N-(2-chloroacetyl)[1-(3,4-dichlorophenyl)cyclobutyl]methylamine (m.p. 104°-105° C.).

Provenance & Evidence