HCID 13279982, compound → HCID 20225028, compound

Participants

Reaction Steps

Borane-methyl sulphide complex (2.48 ml) was added dropwise to a refluxing solution of the acetamide (2.6 g) prepared above in tetrahydrofuran (6 ml). The mixture was heated under reflux for 2 hours left at room temperature for 16 hours and heated under reflux for 2 hours, cooled in ice, and hydrolysed by the slow dropwise addition of ice-water. The mixture was acidified, basified, and extracted with ether. The washed and dried extracts were evaporated to leave an oil which was purified by high pressure liquid chromatography to give N-[(cyclohexyl)(1-phenylcyclobutyl)methyl]-2-methoxyethylamine as a pale yellow oil the physical characteristics of which were not determined.

Provenance & Evidence