Methyl Acrylate → HCID 20225023, compound

Participants

Reaction Steps

A mixture of 1-[1-(3,4-dichlorophenyl)cyclobutyl]butylamine (2 g), methyl acrylate (2 g) and toluene (10 ml) was heated under reflux with stirring for a total of 20 hours. Methyl acrylate (0.5 ml) was added, and heating under reflux and stirring were continued for 3 days. The solvent was removed in vacuo, and the oily residue as purified by chromatography on a silica column using a mixture of 9 parts petroleum ether (b.p. 40°-60°) and 1 part acetone as eluant. From the eluate methyl 3-{1-[1-(3,4-dichlorophenyl)cyclobutyl]butylamino}propanoate was obtained as a pale yellow oil, the physical properties of which were not determined.

Provenance & Evidence