Water → Hydrochloric Acid

Participants

Reaction Conditions

Reaction Steps

Borane-methyl sulphide complex (4 ml) was added under a nitrogen atmosphere to a solution of the amide prepared as above (0.63 g) in dry tetrahydrofuran (50 ml). The mixture was stirred for 16 hours. The residue as cooled to 0° C. and water (30 ml) added and then 2.5N sodium hydroxide solution (30 ml) added. The basic mixture was extracted with ether and the extract was washed, dried filtered and evaporated to give an oil which was dissolved in ether and the solution filtered. Passing hydrogen chloride gas through the solution gave N-ethyl-N-(2-morpholino-ethyl)-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine dihydrochloride hydrate (m.p. 105°-115° C.).

Provenance & Evidence