HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyl cyanide → 2-(3-Bromophenyl)-2-methoxyethan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | 1-Bromo-3-(dimethoxymethyl)benzene | HCID 105395 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Catalyst | zinc(II)iodide | HCID 9883512 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-(3-Bromophenyl)-2-methoxyethan-1-amine | HCID 20225204 | — |
Reaction Steps
1-Methoxy-1-(3-bromophenyl)acetonitrile was prepared from 3-bromobenzaldehyde dimethyl acetal and trimethylsilyl cyanide, using zinc iodide as catalyst, by an analogous procedure to that described in Example X1. Reduction of the acetonitrile with lithium aluminium hydride by an analogous procedure to that described in Example X2 gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04629737 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-9cc7b076408d44caa43e11ed6f07988e |
| Source note | uspto-grants-1986_12 |