Dicyclohexylcarbodiimide → HCID 54041120, compound

HRID 1249223Notes

Reaction equation

HRID 1249223 reaction equation
[CH2:1]([O:8][C:9](=[O:30])[CH2:10][C@H:11]([NH2:29])[C:12](=[O:28])[NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:31][S:32]([NH:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][C:41]([NH:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][C:49](O)=[O:50])=[O:42])(=[O:34])=[O:33].C1CCC(N=C=NC2CCCCC2)CC1>C(Cl)Cl>[CH2:1]([O:8][C:9](=[O:30])[CH2:10][C@H:11]([NH:29][C:49](=[O:50])[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44][NH:43][C:41](=[O:42])[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36][NH:35][S:32]([CH3:31])(=[O:33])=[O:34])[C:12](=[O:28])[NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 202251816-(6-Methanesulfonamidohexanamido)hexanoic acidHCID 53877148HCID 53877148, compound

Product 1

HCID 54041120HCID 54041120, compoundYield 7.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.05 g of (S)-3-amino-3-tetradecylcarbamoylpropionic acid benzyl ester and 1.00 g of 6-(6-methanesulfonamidohexanamido)hexanoic acid were mingled in 20 ml of methylenechloride and after adding thereto 500 mg of DCC and treating the mixuture in the same manner as in Example 26, 140 mg of (S)-3-[6-(6-methanesulfonamidohexanamido)hexanamido]-3-tetradecylcarbamoylpropionic acid benzyl ester was obtained.

Workup

  1. additionafter adding

Sources & evidence

ORD record
ord-1a58c9fa449f416da0e60ff7566ab248
Source dataset
uspto-grants-1986_12
Patent number
US04629736

Reaction notes

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