HRID1249223

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID20225181

未命名化合物

结构：CCCCCCCCCCCCCCNC(=O)[C@@H](N)CC(=O)OCc1ccccc1

HCID53877148

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCNC(=O)[C@H](CC(=O)OCc1ccccc1)NC(=O)CCCCCNC(=O)CCCCCNS(C)(=O)=O

HCID54041120

未命名化合物

收率 7.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

1.05 g of (S)-3-amino-3-tetradecylcarbamoylpropionic acid benzyl ester and 1.00 g of 6-(6-methanesulfonamidohexanamido)hexanoic acid were mingled in 20 ml of methylenechloride and after adding thereto 500 mg of DCC and treating the mixuture in the same manner as in Example 26, 140 mg of (S)-3-[6-(6-methanesulfonamidohexanamido)hexanamido]-3-tetradecylcarbamoylpropionic acid benzyl ester was obtained.

WORKUP

后处理

additionafter adding

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1a58c9fa449f416da0e60ff7566ab248
来源数据集: uspto-grants-1986_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04629736
来源说明: uspto-grants-1986_12

反应 SMILES

[CH2:1]([O:8][C:9](=[O:30])[CH2:10][C@H:11]([NH2:29])[C:12](=[O:28])[NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:31][S:32]([NH:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][C:41]([NH:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][C:49](O)=[O:50])=[O:42])(=[O:34])=[O:33].C1CCC(N=C=NC2CCCCC2)CC1>C(Cl)Cl>[CH2:1]([O:8][C:9](=[O:30])[CH2:10][C@H:11]([NH:29][C:49](=[O:50])[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44][NH:43][C:41](=[O:42])[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36][NH:35][S:32]([CH3:31])(=[O:33])=[O:34])[C:12](=[O:28])[NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1