Ethanol → Ethyl 2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetate

HRID 1249248Notes

Reaction equation

HRID 1249248 reaction equation
[O:1]=[C:2]1[CH2:6][CH:5](C2CCCCO2)[CH2:4][N:3]1[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].C([OH:21])C>>[OH:21][CH:5]1[CH2:4][N:3]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:2](=[O:1])[CH2:6]1

Participants

3

Reactant 2

HCID 702EthanolHCID 53632317HCID 53632317, compound

Product 1

HCID 12365604Ethyl 2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetateYield 62%

Procedure

A solution of 0.16 g ethyl 2-oxo-4-(tetrahydropyran-2-yl)-1-pyrrolidineacetate is dissolved in 5 ml ethanol containing 16 mg pyridinium p-toluenesulphonate. The mixture is heated 4 h at 35° , the ethanol is evaporated and the residue chromatographed on silica. The title compound is obtained as a colourless oil in 62% yield.

Workup

  1. temperatureThe mixture is heated 4 h at 35°
  2. customthe ethanol is evaporated
  3. customthe residue chromatographed on silica

Sources & evidence

ORD record
ord-c226b21ac9904f4b9faaabbdbd614166
Source dataset
uspto-grants-1986_12
Patent number
US04629797

Reaction notes

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