Ammonia → HCID 86741163, compound

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Reaction Steps

The cyclopropyl alanine derivative Boc 3-(3-Chloropropyl) cyclopropyl alanine p-nitrobenzyl Ester (16) is treated with a 1M solution of ammonia in isopropanol at 50° C. in a sealed pressure bottle for 48 hrs. Evaporation of the solution gives a solid residue which is dissolved in warm ethyl acetate (5 ml) and the solution is washed with saturated NaCl solution (3×25 ml) and dried over anhyd. Na2SO4. Evaporation of the solution gives Boc cyclopropyl lysine p-nitrobenzyl ester (17) which recrystallized from ethyl acetate-hexane. NMR (CDCl3) δ: 1.2-1.8 (m, 5H, CH2CH2CH), 0.8-1.1 (m, 2H, CH2), 2.5 (m, 2H, CH2NH2).

Provenance & Evidence