Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | L-Phenylalanine | HCID 6140 | — |
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Product | HCID 178527852 | HCID 178527852 | — |
Reaction Steps
A total of 75 mmoles of Phe in 225 mmoles of ethanol containing 300 mmoles of carbon disulfide and 75 mmoles of solid potassium hydroxide is added with stirring while maintaining the temperature below 40° C. The temperature is then raised to 40° C. and the reaction mixture held in a closed vessel for 12 hours. At the end of this period, the alcohol and carbon disulfide are removed by rotary evaporation. The residue is suspended in a small amount of cold water, and the product recrystallized from the water-ethanol mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04631270 |
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| Source dataset | uspto-grants-1986_12 |
|---|
| ORD ID | ord-37d7053e680a44a18bb157c874189b71 |
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| Source note | uspto-grants-1986_12 |
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