Sodium Hydroxide → HCID 13590769, compound

Participants

Reaction Steps

In a 10-liter reactor there were introduced 6 kg of 50% caustic soda solution, 1,150 g (5.576 moles) of the alcohol of Example 1, 986 g (5.3 moles) of 4-(2-chloroethyl)morpholine hydrochloride and 0.5 g of crown ether 18-crown-6 (1,4,7,10,13,16-hexaoxacycloocta-decane), and the mixture was then brought to 120° C. for 5 hours with stirring. After being cooled, the mixture was extracted with ether and the extract was washed with water dried over Na2SO4 and filtered, the solvent was evaporated and the product distilled under vacuum. There were thus obtained 1,330 g of the title-compound of boiling point 180° C. at a pressure of 65 Pa, having the elementary analysis:

Provenance & Evidence