Sodium Hydroxide → HCID 70352795, compound

Participants

Reaction Steps

A mixture of 6-cyano-3,4-dihydro-2,2-dimethyl-3,4-epoxy-2H-benzo[b]pyran (5.0 g, the preparation of which was described in U.K. patent No. 1,511,187), glycine ethyl ester hydrochloride (2.59 g) and sodium hydroxide (0.75 g) in ethanol (100 mls) was refluxed for 7h. Filtration, evaporation, and chromatography gave the title compound (1.5 g). Recrystaisation of a small portion from ethyl acetate-pentane gave crystals of m.p. 98°-100° C.

Provenance & Evidence