HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 1-{4-[2-Hydroxy-3-(4-phenylpiperazin-1-yl)propoxy]phenyl}propan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | HCID 13603435 | HCID 13603435 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-{4-[2-Hydroxy-3-(4-phenylpiperazin-1-yl)propoxy]phenyl}propan-2-one | HCID 215710 | 92.5% |
Reaction Steps
10.0 g of 4-(2,3-epoxypropoxy)phenylacetone are dissolved in 60 ml of acetone and the solution is heated under reflux with 7.64 g of phenylpiperazine for 3 hours. The mixture is allowed to cool and the product which has crystallised out is filtered off with suction. 16.05 g of 1-[4-(propan-2-on-yl)-phenoxy]-3-(4-phenylpiperazin-1-yl)-propan-2-ol are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04631281 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-dc5846d0c2304e14b83f8074a414bb30 |
| Source note | uspto-grants-1986_12 |