1-(2-Methoxyphenyl)piperazine → HCID 20224533, compound

HRID 1249377Notes

Reaction equation

HRID 1249377 reaction equation
[O:1]1[CH2:15][CH:2]1[CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12](=[O:14])[CH3:13])[CH:8]=[CH:9][CH:10]=1.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[CH2:11]([C:7]1[CH:6]=[C:5]([CH:10]=[CH:9][CH:8]=1)[O:4][CH2:3][CH:2]([OH:1])[CH2:15][N:27]1[CH2:26][CH2:25][N:24]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[O:17][CH3:16])[CH2:29][CH2:28]1)[C:12](=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 23180106HCID 23180106, compound

Product 1

HCID 20224533HCID 20224533, compound

Procedure

3-(2,3-Epoxypropoxy)-phenylacetone is reacted with 2-methoxyphenylpiperazine analogously to Example 2(a). 1-[3-(Propan-2-on-yl)-phenoxy]-3-[4-(2-methoxyphenyl)-piperazin-1-yl]-propan-2-ol is obtained as a syrupy product.

Sources & evidence

ORD record
ord-f584e4a839644b95a23e04ac44e6f4ac
Source dataset
uspto-grants-1986_12
Patent number
US04631281

Reaction notes

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