Nitric Acid → HCID 178486919, compound

HRID 1249383Notes

Reaction equation

HRID 1249383 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[NH:9][C:8](=[O:15])[N:7]=[C:6]2[CH3:16].[N+:17]([O-])([OH:19])=[O:18].OS(O)(=O)=O>>[CH3:1][O:2][C:3]1[C:4]([N+:17]([O-:19])=[O:18])=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[NH:9][C:8](=[O:15])[N:7]=[C:6]2[CH3:16]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 178486917HCID 178486917, compound

Product 1

HCID 178486919HCID 178486919, compound

Procedure

One equivalent of 6,7-dimethoxy-4-methyl-2(1H)quinazolinone is added during 3/4 hr. to a mixture (5:1) of 6 equivalents of concentrated nitric acid (70%) and concentrated H2SO4 at 0°±3° C. After one hour at the same temperature the solution is poured onto crushed ice (1000 ml). The crude product is collected by filtration, digested with boiling alcohol and the suspension is filtered. Crystallization from ethyl alcohol affords 6,7-dimethoxy-5-nitro-4-methyl-2(1H)quinazolinone.

Workup

  1. customat 0°±3° C
  2. additionAfter one hour at the same temperature the solution is poured
  3. filtrationThe crude product is collected by filtration
  4. filtrationthe suspension is filtered
  5. customCrystallization from ethyl alcohol

Sources & evidence

ORD record
ord-c7b223ad49dd4e3f93e7d4b4e6412f92
Source dataset
uspto-grants-1986_12
Patent number
US04631283

Reaction notes

Loading…