Phosphorus trichloride → HCID 88686871, compound

Participants

Reaction Steps

To a solution of benzhydryl 7-t-butoxycarbonylamino-3-[(E)-2-chlorovinyl]-3-cephem-4-carboxylate-1-oxide (7.3 g) in N,N-dimethylformamide (35 ml) was added phosphorus trichloride (1.76 ml) at -40° C. After stirring at the same temperature for 30 minutes, the mixture was poured into ice-water. The resulting precipitate was collected by filtration and dried to give benzhydryl 7-t-butoxycarbonylamino-3-[(E)-2-chlorovinyl]-3-cephem-4-carboxylate (6.3 g).

Provenance & Evidence