Sodium Chloride → HCID 88686710, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of benzhydryl 7-t-butoxycarbonylamino-3-[(E)-2-chlorovinyl]-3-cephem-4-carboxylate (5.0 g) in acetonitrile (50 ml) was added p-toluenesulfonic acid monohydrate (3.23 g). After stirring at 35° C. for 50 minutes, the mixture was poured into a saturated aqueous solution of sodium chloride, adjusted to pH 7.5 with 5% aqueous solution of sodium bicarbonate and extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate and concentrated under reduced pressure. The residue as triturated with n-hexane to give benzhydryl 7-amino-3-[(E)-2-chlorovinyl]-3-cephem-4-carboxylate (2.50 g)

Provenance & Evidence