HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 13654083, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester | HCID 78943 | — |
| Reactant | [4-Chloro-2-(trifluoromethyl)phenyl]hydrazine | HCID 2778240 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 13654083 | HCID 13654083 | 85.9% |
Reaction Steps
A solution of 31.58 g of 2-(trifluoromethyl)-4-chlorophenylhydrazine and 27.92 g of ethyl (ethoxymethylene)cyanoacetate dissolved in 225 ml of acetic acid and 75 ml of water was heated on a steam bath for approximately 16 hours. The reaction mixture was cooled to room temperature and placed in the refrigerator. The precipitated solid was collected by filtrate to provide 43 g of 5-amino-1-[2-(trifluoromethyl)-4-chlorophenyl]-1H-pyrazole-4-carboxylic acid, ethyl ester. mp=114°-116° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04631343 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-e4f53441b38c485a91d1e1f961a9c12b |
| Source note | uspto-grants-1986_12 |