Hydrochloric Acid → HCID 20223426, compound

Participants

Reaction Steps

A mixture of 5-(4-carboxyphenyl)pyrazin-2(1H)-one (1.2 g) and anhydrous methanol was stirred with heating under reflux while a gentle steam of dry hydrogen chloride gas was passed through the solution. After two hours the solvent was evaporated under reduced pressure and the residue was purified by elution from a silica gel column with chloroform/methanol mixtures followed by crystallisation from methanol. This afforded the title compound as a crystalline solid (0.8 g); m.p. 240°-242° C.

Provenance & Evidence