2-Fluoro-4-(1,1,2,2-tetrafluoroethylsulfanyl)aniline → 2,6-Difluoro-N-(((2-fluoro-4-((1,1,2,2-tetrafluoroethyl)thio)phenyl)amino)carbonyl)benzamide

Participants

Reaction Steps

In 20 ml of toluene was dissolved 1.0 g of 2-fluoro-4-(1,1,2,2-tetrafluoroethylthio)aniline, and 0.8 g of 2,6-difluorobenzoyl isocyanate was added dropwise to the solution at room temperature (20° to 25° C.). After the reaction was allowed to proceed at the same temperature for 30 minutes, the crystals, which separated out, were recovered by filtration and washed with toluene to give 1.5 g of N-(2,6-difluorobenzoyl)-N'-[2-fluoro-4-(1,1,2,2-tetrafluoro-ethylthio)phenyl]urea (Compound No. 1), m.p. of 177°-179° C.

Provenance & Evidence