Dichloroacetic Acid → HCID 20223464, compound

Participants

Reaction Steps

A mixture of 10.0 g (0.055 mole) of 4-(1-methylethyl)-5-phenyl-1H-imidazole, 7.61 g (0.06 mole) of dichloroacetic acid and 29.3 g (0.41 mole) of ethyl vinyl ether in 585 ml of toluene was heated at reflux for 3.5 hours. The reaction mixture was cooled to room temperature and was then stirred overnight with 170 ml of 25% aqueous sodium hydroxide. The organic layer was separated. The aqueous was extracted with ether (2×). The organic fractions were combined, washed with brine and dried over anhydrous potassium carbonate. Removal of the solvent under vacuum afforded 13.8 g of an oil, which was used in the subsequent reaction without purification.

Provenance & Evidence