Methanol → HCID 13754490, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5.90 g (14.2 mmol) of 5-(1-methylethyl)-4-(4-methylthiophenyl)-α,α-bis(trifluoromethyl)thiazole-2-methanol in 200 ml of methanol at 25° C. was added 21.3 g (34.7 mmol) of Oxone® (potassium hydrogen persulfate) and the resulting suspension was stirred at 25° C. for 3 hours. The suspension was filtered, and the filtrate concentrated in vacuo. The residue was dissolved in ethyl acetate; and the solution was washed with distilled water and brine, dried over anhydrous magnesium sulfate, filtered and concentrated. The crude product was recrystallized from n-butyl chloride to provide 3.34 g of 5-(1-methylethyl)-4-(4-methylsulfonylphenyl)-α,α-bis(trifluoromethyl)thiazole-2-methanol as a yellow crystalline solid, m.p. 122°-123° C.

Provenance & Evidence