HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-[2,2-Bis(4-fluorophenyl)ethenyl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 13754500 | HCID 13754500 | — |
| Reactant | alpha,alpha-Bis(4-fluorophenyl)-4-piperidineethanol | HCID 13754513 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-[2,2-Bis(4-fluorophenyl)ethenyl]piperidine | HCID 13754503 | — |
Reaction Steps
The title compound was prepared in the same manner as the compound of example 6, starting with 25 g of alpha,alpha-bis(4-fluorophenyl)-4-piperidineethanol, 0.25 molar methylbenzene solvate and 50 mL of trifluoroacetic acid. Crystallization from hexane gave 19.6 g (83%) of the hexane solvate of 4-[2,2-bis(4-fluorophenyl)ethenyl]-piperidine, mp 84°-86° C. Analysis Calculated for C19H19F2N.O.15C6H14 : C, 76.54; H, 6.81; N, 4.49; F, 12.17. Found: C, 76.87; H, 6.72; 4.65; F, 12.12.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04632925 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-95bdbf6fb7a0479f88cdd5c073c7d8a2 |
| Source note | uspto-grants-1986_12 |