3-Pyridinebutanoic acid → 4-(2,2-Diphenylethyl)-1-[1-oxo-4-(3-pyridinyl)butyl]piperidine

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Reaction Steps

The title compound was prepared in a manner similar to that employed for the compound of Example 10 starting with 5.3 g of 4-(2,2-diphenylethyl)piperidine free base and the acid chloride prepared from 5.0 g of 3-pyridine butanoic acid, there was obtained 7.0 g of oil from the toluene extracts. Crystallization from methylene chloride/ether provided 6.3 g (76%) of 4-(2,2-diphenylethyl)-1-[1-oxo-4-(3-pyridinyl)butyl]piperidine, mp 98°-100° C. Analysis Calculated for C28H32N2O: C, 81.51; H, 7.82; N, 6.79. Found: C, 81.43; H, 7.88; N, 6.53.

Provenance & Evidence