6-(Pyrimidin-5-yl)hexan-1-ol → 5-[6-[4-(2,2-Diphenylethenyl)-1-piperidinyl]hexyl]pyrimidine

Participants

Reaction Steps

The title compound was prepared in a manner similar to that employed for the compound of Example 23 starting with 7.4 g of 4-(2,2-diphenylethenyl)piperidine and 5.9 g of 5-(6-chlorohexyl)pyrimidine, from 5-pyrimidinehexanol. Chromatography provided 5.9 g (50%) of crude 5-[6-[4-(2,2-diphenylethenyl)-1-piperidinyl]hexyl]pyrimidine. Crystallization from hexane provided the analytically pure 5-[6-[4-(2,2-diphenylethenyl)-1-piperidinyl]hexyl]pyrimidine, mp 88°-90° C. Analysis Calculated for C29H35N3 : C, 81.84; H, 8.29; N, 9.87. Found: C, 81.90; H, 8.31; N, 9.78.

Provenance & Evidence