Sodium Hydroxide → HCID 178432636, compound

HRID 1249604Notes

Reaction equation

HRID 1249604 reaction equation
Br.[NH:2]([C:6]1[S:7][CH:8]=[C:9]([C:11]2[N:12]=[C:13]([CH3:16])[NH:14][CH:15]=2)[N:10]=1)[C:3]([NH2:5])=[NH:4].[OH-].[Na+]>O>[NH:2]([C:6]1[S:7][CH:8]=[C:9]([C:11]2[N:12]=[C:13]([CH3:16])[NH:14][CH:15]=2)[N:10]=1)[C:3]([NH2:5])=[NH:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178419520HCID 178419520, compound

Product 1

HCID 178432636HCID 178432636, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Guanidino-4-(2-methyl-4-imidazolyl)thiazole monohydrobromide (360.7 g, 1.19 mole; U.S. Pat. No. 4,374,843) was slurried in 7500 ml H2O for 15 minutes at 19° C. With stirring, the pH was slowly adjusted from 5.8 to a stable value of 9.5 with 10% NaOH, 500±5 ml being required. After stirring a further 0.5 hours, title product was recovered by filtration on sintered glass. The sticky cake was washed with 2000 ml H2O, pulled to a tight cake and finally washed with 1000 ml of hexane. After air drying on the funnel for 18 hours, the entire still-partially-wet cake was taken into the next step.

Workup

  1. stirringAfter stirring a further 0.5 hours
  2. filtrationtitle product was recovered by filtration on sintered glass
  3. washThe sticky cake was washed with 2000 ml H2O
  4. washfinally washed with 1000 ml of hexane
  5. customAfter air drying on the funnel for 18 hours

Sources & evidence

ORD record
ord-734653cd570e4b40b285419aa45025bd
Source dataset
uspto-grants-1986_12
Patent number
US04632993

Reaction notes

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