反应详情

2-Guanidino-4-(2-methyl-4-imidazolyl)thiazole dihydrobromide (13.4 g) was stirred with 66.9 ml H2O and the pH slowly adjusted to a stable value of 10.0 over 2 hours with 22.6 ml of 3N NaOH while maintaining a temperature of 22°-24° C. Title product was recovered by suction filtration with water wash, pulled to a tight cake under a rubber dam, repulped in 28 ml acetone for 2 hours, refiltered, washed with 12 ml acetone and dried at 40° C. in vacuum to yield crystalline title product, 8.66 g, containing about 15% water.

1. temperaturewhile maintaining a temperature of 22°-24° C
2. filtrationTitle product was recovered by suction filtration with water
3. washwash
4. washwashed with 12 ml acetone
5. customdried at 40° C. in vacuum