Hydroxyamine hydrochloride → 5-[2-Chloro-4-(trifluoromethyl)phenoxy]2-nitrobenzaldehyde oxime

Participants

Reaction Steps

To a solution of hydroxylamine hydrochloride (0.33 g., 0.0048 mole) and sodium acetate (0.394 g., 0.0048 mole) in 2-3 ml of water was added a hot solution of 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzaldehyde (1.5 g., 0.00434 mole) in ethanol (10-12 ml). The clear yellow solution was heated for 1.5 hours and then the solvent was stripped on a rotary evaporator to give a yellow waxy solid which solidified giving 1.5 g., mp. 111°-115° C. Recrystallization from ethanol/water gave a solid mp. 114°-118° C.

Provenance & Evidence