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Hydroxylamine → HCID 13340177、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydroxylamine | HCID 787 | — |
| 反応物 | N-(1,1-Dimethylethyl)benzenemethanamine | HCID 76908 | — |
| 反応物 | 6-(1,2-epoxyethyl)-2-phenyl-4H-1,3-dioxino[5,4-b]pyridine | HCID 13748403 | — |
| 反応物 | HCID 53930912 | HCID 53930912 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 13340177 | HCID 13340177 | — |
反応手順
A solution of 33.0 g. (0.13 mole) 6-(1,2-epoxyethyl)-2-phenyl-4H-1,3-dioxino-[5,4-b]pyridine and 22.0 g. (0.135 mole) of N-tert-butylbenzylamine in 200 ml. of methanol was heated to the reflux temperature overnight. Upon cooling there deposited 6-[1- hydroxy-2-(N-tert-butylbenzylamino)ethyl]pyridine which was recrystallized from isopropanol to give 29.4 g. (54%) of the amino alcohol m.p. 126°-130° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04632992 |
| 出典データセット | uspto-grants-1986_12 |
| ORD ID | ord-e286de22e5854b9da3b1fae569df5f35 |
| 出典メモ | uspto-grants-1986_12 |