N,N-Dimethylglycine → HCID 86757698, compound
Reaction equation
[CH3:1][N:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].[NH2:8][C@H:9]([C:14]([OH:16])=[O:15])[C:10]([CH3:13])([CH3:12])[CH3:11].[NH2:17][CH2:18][C:19]([OH:21])=[O:20].[NH2:22][C@H:23]([C:26]([OH:28])=[O:27])[CH2:24][SH:25].[CH3:29][N:30]([CH3:35])[CH2:31][C:32]([OH:34])=[O:33]>>[CH3:1][N:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].[NH2:8][C@H:9]([C:14]([OH:16])=[O:15])[C:10]([CH3:13])([CH3:12])[CH3:11].[NH2:22][C@H:23]([C:26]([OH:28])=[O:27])[CH2:24][SH:25].[NH2:17][CH2:18][C:19]([OH:21])=[O:20].[CH3:29][N:30]([CH3:35])[CH2:31][C:32]([OH:34])=[O:33].[NH2:2][C@@H:3]([C:4]([OH:6])=[O:5])[C:10]([CH3:12])([CH3:11])[CH3:9].[NH2:2][C@H:3]([C:4]([OH:6])=[O:5])[CH2:24][SH:25].[NH2:2][CH2:3][C:4]([OH:6])=[O:5]Participants
Procedure
In the coordination of dimethylglycine-t-butylglycine-cysteine-glycine [SEQ ID NO:1] to TcO3+ and ReO3+, an single isomer was observed. A single pair of singlets associated with the methyl groups in the dimethylglycine residue was observed. The 1H and 13C NMR spectral data for the Re oxo complex of dimethylglycine-L-t-butylglycine-L-cysteine-glycine [SEQ ID NO:2]. The 99mTc labeling of dimethylglycine-L-t-butylglycine-L-cysteine-glycine [SEQ ID NO:2] (RP455) and of dimethylglycine-D-t-butylglycine-L-cysteine-glycine [SEQ ID NO:3] (RP505) produced a single peak as observed in the HPLC using the radiometric detector. This was an unexpected result and is in contrast with what is observed in the Tc and Re oxo complexes of other tetradentate N4−xSx chelators,9, 39-55 which exist as the syn and anti isomers.
Sources & evidence
- ORD record
- ord-15ab498bb9244085a4531cdfc44f095a
- Source dataset
- uspto-grants-2002_01
- Patent number
- US06334996B1
Reaction notes
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