Tetrahydrofuran → HCID 18328912, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of oil 1-benzyloxycarbonyl-4-ethoxycarbonyl-piperazine (30 g) in tetrahydrofuran (200 ml) was added lithiumborohydride (2.7 g) and stirred at 60° C. for 5 hours. To quench thc mixture, added methanol, dilute hydrochloric acid and then concentrated hydrochloric acid. Diluted with diethylether and resulting suspension washed with water (×2) dilute sodiumbicarbonate then brine, dried (MgSO4) and evaporated to give as a colourless oil oil 1-benzyloxycarbonyl-4-hydroxy-piperazine (23 g) which was used directly in the next step without further purification or characterisation.

Provenance & Evidence