HCID 18328917, compound → HCID 18328913, compound

HRID 1249733Notes

Reaction equation

HRID 1249733 reaction equation
Cl.[CH3:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][C:12]([CH2:16][N:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)([OH:15])[CH2:11][CH2:10]2)[CH:6]=[CH:5][N:4]=1.[F:23][C:24]1[CH:35]=[CH:34][C:27]([C:28](S(Cl)(=O)=O)=[O:29])=[CH:26][CH:25]=1>>[F:23][C:24]1[CH:35]=[CH:34][C:27]([C:28]([N:20]2[CH2:21][CH2:22][N:17]([CH2:16][C:12]3([OH:15])[CH2:11][CH2:10][N:9]([C:7]4[CH:6]=[CH:5][N:4]=[C:3]([CH3:2])[N:8]=4)[CH2:14][CH2:13]3)[CH2:18][CH2:19]2)=[O:29])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 18328917HCID 18328917, compoundHCID 18328940HCID 18328940, compound

Product 1

HCID 18328913HCID 18328913, compound

Procedure

Using an analogous procedure to that described in Example 14, 1-(2-methylpyrimidin-4-yl)-4-(1-piperazinomethyl)piperidin-4-ol hydrochloride was reacted with 4-fluorobenzoylsulphonyl chloride to give 1-(4-fluorobenzoyl)-4-[1-(2-methylpyrimidin-4-yl]-4-hydroxy-4-piperidylmethyl]piperazine m.p. 114-117° C.

Sources & evidence

ORD record
ord-c12961dafad4412f8cf02498794b854b
Source dataset
uspto-grants-2002_01
Patent number
US06335341B1

Reaction notes

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