Hydrochloric Acid → HCID 70156073, compound

Participants

Reaction Steps

1-(4-Bromophenylsulphonyl)-4-[1-(6-methylpyrimidin-4-yl)-4-piperidylcarbonyl]piperazine (630 mg) suspended in dry THF (10 ml) was treated with excess borane methyl sulphide complex (0.59 ml) at ambient temprature, then at 45° C. for 18 hours. 5M HCl (1.0 ml) was added and stirred for 2 hours. The reaction mixture was basified with 4M NaOH solution. then partitioned between ethylacetate and water. dried (MgSO4), and evaporated. The residue was chromatographed on Bondelut (CH2Cl2 then 1% MeOH/CH2Cl2,2% MeOH/CH2Cl2) to give 1-(4-bromophenylsulphonyl)-4-[1-(6-methylpyrimidin-4-yl)-4-piperidylmethyl]piperazine (276 mg) as a gum.

Provenance & Evidence