HCID 18184366, compound → HCID 18184387, compound

Participants

Reaction Steps

Scheme 2 can be illustrated with reference to the preparation of 4-oxo-3H-oxazolo[5,4-g]quinazoline. In this process, 5-hydroxy-2,4-dinitrobenzamide (compound of formula VIII in which Y1 is amino, Y2 is O, Y4 is hydroxy and Y5 is nitro) is hydrogenated over 5% palladium over carbon at about 60 psi for about 3 hours to give 2,4-diamino-5-hydroxybenzamide. To this product is added formic acid and the mixture is heated to reflux for about 48 hours to provide 4-oxo-3H-oxazolo[5,4-g]quinazoline. In this process, steps 1 and 2 of Scheme 2 are performed as a single step.

Provenance & Evidence